Adriano Aguzzi - Profile and Journalist Details
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Adriano Aguzzi
Verified
Editor-in-Chief, Swiss Medical Weekly
Zurich, Zürich
Beats
datajournalism
Content
By Carlo Scialo, Weijia Zhong, Somanath Jagannath, Oscar G. Wilkins, Davide Caredio, Marian Hruska-Plochan, Flavio Lurati, Martina Peter, Elena De Cecco, Luigi Celauro, Adriano Aguzzi Verified, Giuseppe Legname, Pietro Fratta, Magdalini Polymenidou| Cell Press Verified Keywords TDP-43 low-complexity domain RNA-binding proteins aggregation seeding spreading loss of function cryptic splicing neurodegeneration ALS/FTD Introduction Despite apparent differences, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasingly recognized to have clinical, genetic, and pathological overlap.1 Transactive response DNA-binding protein of 43 kDa (TDP-43) is the major component of ubiquitinated cytoplasmic inclusions observed in both ALS and FTD...
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons - Nature Microbiology
By Shahar Bracha, Athena Economides, Daniel Walsh, Adriano Aguzzi Verified, Lilach Sheiner| Nature Verified AbstractDelivering macromolecules across biological barriers such as the blood–brain barrier limits their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite that naturally travels from the human gut to the central nervous system (CNS), can deliver proteins to host cells. Here we engineered T.
By Carlo Scialo, Weijia Zhong, Somanath Jagannath, Oscar G. Wilkins, Davide Caredio, Marian Hruska-Plochan, Flavio Lurati, Martina Peter, Elena De Cecco, Luigi Celauro, Adriano Aguzzi Verified, Giuseppe Legname, Pietro Fratta, Magdalini Polymenidou| Cell Press Verified Keywords TDP-43 low-complexity domain RNA-binding proteins aggregation seeding spreading loss of function cryptic splicing neurodegeneration ALS/FTD Introduction Despite apparent differences, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasingly recognized to have clinical, genetic, and pathological overlap.1 Transactive response DNA-binding protein of 43 kDa (TDP-43) is the major component of ubiquitinated cytoplasmic inclusions observed in both ALS and FTD...
Company Info
Swiss Medical Weekly
Established in 1871. Diamond Open Access since 2001. Published by the SMW supporting association, a non-profit organisation.
Basel, Basel City, Switzerland
+41 61 467 85 55
Founded: 1871