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Alexandra Flemming
Verified
Chief Editor, Nature Reviews Immunology
London
Beats
geopolitics, human rights boxing history,organized crime philosophy, sociology history of martial arts
Content
By Alexandra Flemming| Nature Verified The meninges form a three-layered structure that covers the brain and spinal cord and contains large numbers of immune cells, especially in its outer layer, the dura mater. These meningeal immune cells are known to affect brain responses to ageing, injury and infection. Mathis and colleagues now show that regulatory T (Treg) cells in the meninges are important regulators of brain homeostasis.
By Alexandra Flemming| Nature Verified Cytotoxic T lymphocytes (CTLs) in tumours are often dysfunctional. Bréart et al. investigated the association between cytokines and CTLs in human tumours and found a correlation between IL27 expression and CTL infiltration. In syngeneic mouse models, treatment with an IL-27-encoding plasmid or half-life-enhanced IL-27, with or without anti-PD-L1, improved tumour rejection without overt toxicity.
By Alexandra Flemming| Nature Verified The meninges form a three-layered structure that covers the brain and spinal cord and contains large numbers of immune cells, especially in its outer layer, the dura mater. These meningeal immune cells are known to affect brain responses to ageing, injury and infection. Mathis and colleagues now show that regulatory T (Treg) cells in the meninges are important regulators of brain homeostasis.
Company Info
Nature Reviews Immunology
London, England, United Kingdom
+44 20 7833 4000