Alexandra Tremblay - Profile and Journalist Details
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Host, CKYK-FM (Alma, QC)
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Content
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice
By Shuo Niu, Zhen Bian, Alexandra Tremblay, Youqun Luo| The Journal of Immunology Verified Chronic diseases are often associated with altered inflammatory response, leading to increased host vulnerability to new inflammatory challenges. Employing streptozotocin (STZ)-induced diabetes as a model, we further investigate mechanisms leading to enhanced neutrophil (polymorphonuclear leukocytes [PMN]) responses under hyperglycemia and compare them with those under chronic colitis.
Controlling macrophage phagocytosis towards healthy self cells: Two layers of activating and inhibitory mechanisms
By Zhen Bian, Alexandra Tremblay, Shuo Niu, Zhiyuan Lv, Ke Zen| The Journal of Immunology Verified Rapid clearance of adoptively transferred CD47-null cells in mice suggests a critical self-recognition mechanism, in which CD47 is the ubiquitous marker of ‘self’, and its interaction with macrophage SIRPα triggers inhibitory signaling through SIRPα cytoplasmic ITIMs and tyrosine phosphatase SHP-1/2.
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice
By Shuo Niu, Zhen Bian, Alexandra Tremblay, Youqun Luo| The Journal of Immunology Verified Chronic diseases are often associated with altered inflammatory response, leading to increased host vulnerability to new inflammatory challenges. Employing streptozotocin (STZ)-induced diabetes as a model, we further investigate mechanisms leading to enhanced neutrophil (polymorphonuclear leukocytes [PMN]) responses under hyperglycemia and compare them with those under chronic colitis.
Company Info
CKYK-FM (Alma, QC)