Andrew Brennan - Profile and Journalist Details
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Andrew Brennan
Verified
Anchor and Reporter, CP24
Toronto
Beats
Everything not related to fall color.
Content
Enhancing the efficacy, utility and throughput of the Transcription Block Survival peptide library screening platform
By Andrew Brennan Verified, Jody M Mason| bioRxiv@ AbstractGenetically encoded peptide library screening is a powerful strategy for discovering inhibitors of protein-protein and protein-DNA interactions. The Transcription Block Survival (TBS) assay enables the in vivo selection of peptides that antagonise transcription factor (TF) binding by linking inhibition of DNA-binding to E.coli survival. However, previous TBS implementations required laborious re-engineering of the mDHFR coding region for each new target, limiting utility.
An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors
By Andrew Brennan Verified, Scott D. Lovell, Keith Vance, Jody M Mason| Wiley Online Library Verified 1 Introduction Peptides are increasingly asserting their utility as therapeutic lead molecules to target challenging intracellular protein targets.[1] The effectiveness of peptides in targeting protein interaction surfaces is now well established due to their ability to bind to broader and shallower interfaces than small molecules, with enhanced binding affinity and selectivity.
Enhancing the efficacy, utility and throughput of the Transcription Block Survival peptide library screening platform
By Andrew Brennan Verified, Jody M Mason| bioRxiv@ AbstractGenetically encoded peptide library screening is a powerful strategy for discovering inhibitors of protein-protein and protein-DNA interactions. The Transcription Block Survival (TBS) assay enables the in vivo selection of peptides that antagonise transcription factor (TF) binding by linking inhibition of DNA-binding to E.coli survival. However, previous TBS implementations required laborious re-engineering of the mDHFR coding region for each new target, limiting utility.
Company Info
CP24
Breaking news from Toronto and across the GTA, live from CP24's headquarters at 299 Queen Street West.
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