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Contributor, BU Pipe Dream
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By Keenan Pearson, Sarah K. Jachim, Caroline Doherty, Brandon Wilbanks| bioRxiv@ AbstractCellular senescence is an irreversible form of cell-cycle arrest caused by excessive stress or damage. While various biomarkers of cellular senescence have been proposed, there are currently no universal, stand-alone indicators of this condition. The field largely relies on the combined detection of multiple biomarkers to differentiate senescent cells from non-senescent cells.
By Steven C. Munger, Caroline Doherty, Diana J. Laird, Abdulfatai Tijani| bioRxiv@ AbstractIt is currently thought that growing mammalian oocytes receive only small molecules via gap junctions from surrounding support cells, the granulosa cells. From the study of chimeric preantral oocyte and granulosa cell reaggregations, we provide evidence that growing mouse oocytes receive mRNAs from granulosa cells. Among the >1,000 granulosa-transcribed RNAs we identified in the oocyte, those that contribute to proper oocyte maturation and early embryo development were highly enriched.
By Keenan Pearson, Sarah K. Jachim, Caroline Doherty, Brandon Wilbanks| bioRxiv@ AbstractCellular senescence is an irreversible form of cell-cycle arrest caused by excessive stress or damage. While various biomarkers of cellular senescence have been proposed, there are currently no universal, stand-alone indicators of this condition. The field largely relies on the combined detection of multiple biomarkers to differentiate senescent cells from non-senescent cells.
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BU Pipe Dream