Colleen Phelan - Profile and Journalist Details
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Colleen Phelan
Verified
Co-Host, Planner Girl Chatter
Beats
celebrities, social mediacelebrity, fashion lifestyle, women's issues technology, relationships work
engineering, computer science, hard core science, accounting
Content
By Sayantan Banerjee, Colleen Phelan, Brian Reese, Michelle Conroy| Wiley Online Library Verified To the Editor, IgE binds FcεRI monomerically with high affinity.1-4 A recent manuscript interrogated interactions between IgE and FcεRI using sandwich ELISA and flow cytometry,5 methods which quantify the amount of IgE bound to FcεRI, but not interaction strength. The authors found more asialylated IgE bound FcεRI than sialylated IgE at saturating levels in both assays. Therefore, we asked whether removing sialic acid enabled binding of multiple IgE to FcεRI.
By Sayantan Banerjee, Colleen Phelan, Brian Reese, Michelle Conroy| Wiley Online Library Verified To the Editor, IgE binds FcεRI monomerically with high affinity.1-4 A recent manuscript interrogated interactions between IgE and FcεRI using sandwich ELISA and flow cytometry,5 methods which quantify the amount of IgE bound to FcεRI, but not interaction strength. The authors found more asialylated IgE bound FcεRI than sialylated IgE at saturating levels in both assays. Therefore, we asked whether removing sialic acid enabled binding of multiple IgE to FcεRI.
Company Info
Planner Girl Chatter