Colm A. Ryan - Profile and Journalist Details
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Colm A. Ryan
Verified
Journalist, AgriLand
Wexford
Beats
Content
Benchmarking Genetic Interaction Scoring Methods for Identifying Synthetic Lethality from Combinatorial CRISPR Screens
By Hamda B Ajmal, Sutanu Nandi, Narod Kebabci, Colm A. Ryan Verified| bioRxiv@ AbstractSynthetic lethality (SL) is an extreme form of negative genetic interaction, where simultaneous disruption of two non-essential genes causes cell death. SL can be exploited to develop cancer therapies that target tumour cells with specific mutations, potentially limiting toxicity. Pooled combinatorial CRISPR screens, where two genes are simultaneously perturbed and the resulting impacts on fitness estimated, are now widely used for the identification of SL targets in cancer.
By Colm A. Ryan Verified| Medium@ Colm Ryan·Follow2 min read·--I just read an article by Joe Humphreys in the Irish Times that got me thinking. He was talking about the Pareto Principle or the 80/20 rule and how it wasn’t some sort of guide for life, just a general observation on how things in life tends to organise itself. I agree with Joe’s view here, and I just wish to add to it. I’m well accustomed to the 80/20 rule from a business context.
Benchmarking Genetic Interaction Scoring Methods for Identifying Synthetic Lethality from Combinatorial CRISPR Screens
By Hamda B Ajmal, Sutanu Nandi, Narod Kebabci, Colm A. Ryan Verified| bioRxiv@ AbstractSynthetic lethality (SL) is an extreme form of negative genetic interaction, where simultaneous disruption of two non-essential genes causes cell death. SL can be exploited to develop cancer therapies that target tumour cells with specific mutations, potentially limiting toxicity. Pooled combinatorial CRISPR screens, where two genes are simultaneously perturbed and the resulting impacts on fitness estimated, are now widely used for the identification of SL targets in cancer.
Company Info
AgriLand
AGRILAND FS is a farmer-owned cooperative based in Winterset, Iowa, with over 90 years of experience. The organization operates across Southern Iowa, Northwest Missouri, and other areas in the Midwest, generating a revenue of $79.4 million and employing 231 people. AGRILAND FS is dedicated to supporting farmers and local communities with a wide range of products and services. The company offers agronomy services that leverage digital technology for innovative solutions, energy solutions including propane and fuel, and grain services for storage and marketing. Additionally, AGRILAND FS provides customized financing through FS Agri-Finance to enhance profitability for agricultural businesses. Their product lineup includes high-quality seeds, fertilizers, agricultural chemicals, and petroleum products. The cooperative also focuses on sustainability, ensuring that its operations benefit both the environment and the community.
Cavan
+1 515-462-5353
Founded: 1931