David Loughrey - Profile and Journalist Details
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David Loughrey
Verified
Contributor, Freelance
Beats
gaming hardware tech
Arts & Society
Content
By David Loughrey, Kalina Paunovska, Elisa Schrader Echeverri, Karen E Tiegreen| Royal Society of Chemistry Verified The time course of in vivo cellular responses to LNPs Cells actively respond to drug delivery systems. However, the time course of cellular responses to lipid nanoparticles (LNPs) remains unclear. Here we characterized the transcriptomic response to LNPs carrying mRNA at different timepoints in vivo. Exposure to LNPs altered the expression of signaling pathways including endocytosis and lysosomal pathways as soon as one hour after administration.
By Guo Ying, David Loughrey, David Geldmacher, Nattawan Utoomprurkporn| Frontiers@ 1. IntroductionAge-related hearing loss (ARHL) is a prevalent complex sensory deficit among older adults, resulting from the cumulative effects of aging on the auditory system (Bowl and Dawson, 2019). The deprivation of hearing in older adults due to ARHL could distance them from regular social activities, potentially leading to social isolation, loneliness, cognitive impairment, and an elevated risk of frailty and falls (Kamil et al., 2016; Rutherford et al., 2018).
By David Loughrey, Kalina Paunovska, Elisa Schrader Echeverri, Karen E Tiegreen| Royal Society of Chemistry Verified The time course of in vivo cellular responses to LNPs Cells actively respond to drug delivery systems. However, the time course of cellular responses to lipid nanoparticles (LNPs) remains unclear. Here we characterized the transcriptomic response to LNPs carrying mRNA at different timepoints in vivo. Exposure to LNPs altered the expression of signaling pathways including endocytosis and lysosomal pathways as soon as one hour after administration.
Company Info
Freelance
Freelancer.com is the largest freelancing and crowdsourcing marketplace in the world, connecting over 81 million employers and freelancers across more than 247 countries. Founded in 2009 and based in Sydney, Australia, the platform allows employers to post jobs while freelancers can bid on these projects. It is publicly traded on the Australian Securities Exchange under the ticker ASX:FLN. The platform supports a variety of work categories, including software development, writing, design, and marketing. Freelancer.com also offers contests for creative work, where employers can award prize money to winning entries. Users can choose from different membership plans, including free and paid subscriptions, which provide various benefits. The mobile app enhances project management and communication for users on the go. With a diverse customer base that includes individuals, small businesses, and large enterprises, Freelancer.com plays a significant role in the global online economy.
De Pere, Wisconsin, United States