Hanson Lee - Profile and Journalist Details
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Hanson Lee
Verified
Bellevue
Beats
Beauty Music LifestyleTravel Marketing
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Content
By Hanson Lee, Bryanna L. Samolyk, George D. Pins| MDPI@ All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Engineering of highly active and diverse nuclease enzymes by combining machine learning and ultra-high-throughput screening
By Neil Thomas, David Belanger, Chenling Xu, Hanson Lee| bioRxiv@ AbstractOptimizing enzymes to function in novel chemical environments is a central goal of synthetic biology, but optimization is often hindered by a rugged, expansive protein search space and costly experiments. In this work, we present TeleProt, an ML framework that blends evolutionary and experimental data to design diverse protein variant libraries, and employ it to improve the catalytic activity of a nuclease enzyme that degrades biofilms that accumulate on chronic wounds.
By Hanson Lee, Bryanna L. Samolyk, George D. Pins| MDPI@ All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Company Info
London, England, United Kingdom
+44 20 3946 7418