Ian MacArthur - Profile and Journalist Details
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Ian MacArthur
Verified
Senior Producer, CHFI-FM
Netherlands, Pereira
Beats
Gaming , Hardware , Mobile, Xbox
Cryptocurrency, Investing
Content
Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence
By Matthew Du, Reo Higashi, Rebekah A. Warwick, Ian MacArthur Verified| Science Magazine Verified AbstractDNA methylation is extensively reconfigured during development, but the functional significance and cell type–specific dependencies of DNA demethylation in lineage specification remain poorly understood. Here, we demonstrate that developmental DNA demethylation, driven by ten-eleven translocation 1/2/3 (TET1/2/3) enzymes, is essential for establishment of neural stem cell (NSC) identity and gliogenic potential.
By Heathcliff Dorado Garcia, Yi Bei, Koshi Imami, Konstantin Helmsauer, Ian MacArthur Verified, Angelika Eggert, Marieluise Kirchner, Philipp Mertins, Matthias Selbach, Johannes H. Schulte, Simone Spuler, Andrew Kung, Kerstin Haase, Fabian Pusch, Jennifer von Stebut, Michela DiVirgilio| Nature Verified AbstractDespite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 related protein (ATR) inhibition.
Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence
By Matthew Du, Reo Higashi, Rebekah A. Warwick, Ian MacArthur Verified| Science Magazine Verified AbstractDNA methylation is extensively reconfigured during development, but the functional significance and cell type–specific dependencies of DNA demethylation in lineage specification remain poorly understood. Here, we demonstrate that developmental DNA demethylation, driven by ten-eleven translocation 1/2/3 (TET1/2/3) enzymes, is essential for establishment of neural stem cell (NSC) identity and gliogenic potential.
Company Info
CHFI-FM