James Schofield - Profile and Journalist Details
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James Schofield
Verified
Editor, Corridor8
Beats
Food , Drinks
N/A. I am open to all topics!
Content
Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides
By James Schofield, Notre Dame, Joseph Longo Verified, Ryan D. Sheldon| Cell Reports Verified Highlights•Cancerous epithelial cells can express Acod1 and produce itaconate•Acod1 loss in αPD-1-resistant tumors resensitizes them to therapy•Acod1hi cells inhibit naive CD8+ T cell activation independent of itaconate•Acod1hi cells suppress T cells by secreting inhibitory peptidesSummaryTargeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches.
Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides
By James Schofield, Joseph Longo Verified, Ryan D. Sheldon, Emma Albano| bioRxiv@ AbstractTargeting PD-1 is an important component of many immune checkpoint blockade (ICB) therapeutic approaches. However, ICB is not an efficacious strategy in a variety of cancer types, in part due to immunosuppressive metabolites in the tumor microenvironment (TME). Here, we find that anti-PD-1-resistant cancer cells produce abundant itaconate (ITA) due to enhanced levels of aconitate decarboxylase (Acod1).
Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides
By James Schofield, Notre Dame, Joseph Longo Verified, Ryan D. Sheldon| Cell Reports Verified Highlights•Cancerous epithelial cells can express Acod1 and produce itaconate•Acod1 loss in αPD-1-resistant tumors resensitizes them to therapy•Acod1hi cells inhibit naive CD8+ T cell activation independent of itaconate•Acod1hi cells suppress T cells by secreting inhibitory peptidesSummaryTargeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches.
Company Info
Corridor8
Contemporary visual art and writing magazine
United Kingdom