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Jean-Laurent Casanova
Verified
Editor-in-Chief, Journal of Clinical Immunology
New York
Beats
crime and courts,environment native american/indigenous peoples, religion texas, politics
I really have none.
Content
Post-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles
By Svenja Weiss, Hung-Mo Lin, Eric Acosta, Natalia L. Komarova, Ping Chen, Dominik Wodarz, Ian L Baine, Ralf Duerr, Ania Wajnberg, Adrian Gervais, Paul Bastard, Jean-Laurent Casanova Verified, Talia Swartz, Judith Aberg, Nicole M. Bouvier, Suzanne A. Arinsburg| The Journal of Clinical Investigation@ AbstractEarly antibody therapy can prevent severe SARS-CoV-2 infection (COVID-19). However, the effectiveness of COVID-19 convalescent plasma (CCP) therapy in treating severe COVID-19 remains inconclusive. To test a hypothesis that some CCP units are associated with a coagulopathy hazard in severe disease that offsets its benefits, we tracked 304 CCP units administered to 414 hospitalized COVID-19 patients to assess their association with the onset of unfavorable post-transfusion D-dimer trends.
By Rocio Vicario, Stamatina Fragkogianni, Maria Pokrovskii, Carina Meyer, Estibaliz Lopez-Rodrigo, Yang Hu, Masato Ogishi, Araitz Alberdi, Ann Baako, Oyku Ay, Isabelle Plu, Véronique Sazdovitch, Sébastien Heritier, Fleur Cohen-Aubart, Natalia Shor, Makoto Miyara, Florence Nguyen-Khac, Agnes Viale, Ahmed Idbaih, Zahir Amoura, Marc K. Rosenblum, Haochen Zhang, Elias-Ramzey Karnoub, Palash Sashittal, Akhil Jakatdar, Christine A. Iacobuzio-Donahue, Omar Abdel-Wahab Verified, Viviane Tabar, Nicholas D. Socci, Olivier Elemento, Eli L. Diamond, Bertrand Boisson, Jean-Laurent Casanova Verified, Danielle Seilhean, Julien Haroche, Jean Donadieu, Frederic Geissmann| Cell Press Verified Keywords Neurodegeneration MAPK pathway microglia hippocampus brainstem resident macrophages Introduction Langerhans cell histiocytosis (LCH)1 and Erdheim-Chester disease (ECD)2,3 are rare clonal myeloid disorders, with an estimated incidence of ∼5 cases per million people per year.4 They are sometimes co-diagnosed in the same patients,5 and both associated with a high prevalence of the BRAFV600E mutation1,2,3,6,7,8 as well as an increased risk of neurodegenerative disease...
Post-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles
By Svenja Weiss, Hung-Mo Lin, Eric Acosta, Natalia L. Komarova, Ping Chen, Dominik Wodarz, Ian L Baine, Ralf Duerr, Ania Wajnberg, Adrian Gervais, Paul Bastard, Jean-Laurent Casanova Verified, Talia Swartz, Judith Aberg, Nicole M. Bouvier, Suzanne A. Arinsburg| The Journal of Clinical Investigation@ AbstractEarly antibody therapy can prevent severe SARS-CoV-2 infection (COVID-19). However, the effectiveness of COVID-19 convalescent plasma (CCP) therapy in treating severe COVID-19 remains inconclusive. To test a hypothesis that some CCP units are associated with a coagulopathy hazard in severe disease that offsets its benefits, we tracked 304 CCP units administered to 414 hospitalized COVID-19 patients to assess their association with the onset of unfavorable post-transfusion D-dimer trends.
Company Info
Journal of Clinical Immunology
Englewood Cliffs, United States