Joseph Varriale - Profile and Journalist Details
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Joseph Varriale
Verified
Host, Hopkins Biotech Podcast
Beats
home entertainment, mobile telecommunicationsCovers: auto, smartphones television, tablets
Anything outside Wales!
Content
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
By Natalie McMyn, Joseph Varriale, Emily J. Fray, Carolin Zitzmann| The Journal of Clinical Investigation@ ResearchIn-Press PreviewAIDS/HIVVirologyOpen Access | 10.1172/JCI171554@ J Clin Invest. https://doi.org/10.1172/JCI171554. Copyright © 2023, McMyn et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
By Natalie McMyn, Joseph Varriale, Emily J. Fray, Carolin Zitzmann| The Journal of Clinical Investigation@ HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first seven years of ART (t1/2 = 44 months). However, whether decay continues with long-term ART is unclear. Recent integration site studies indicate gradual selection against inducible, intact proviruses, raising speculation that decades of ART might allow treatment interruption without viral rebound.
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
By Natalie McMyn, Joseph Varriale, Emily J. Fray, Carolin Zitzmann| The Journal of Clinical Investigation@ ResearchIn-Press PreviewAIDS/HIVVirologyOpen Access | 10.1172/JCI171554@ J Clin Invest. https://doi.org/10.1172/JCI171554. Copyright © 2023, McMyn et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Company Info
Hopkins Biotech Podcast
United States, United States
+1 713-348-4357
Founded: 2003