Lu-Hai Wang - Profile and Journalist Details
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Lu-Hai Wang
Verified
Associate Editor, Journal of Biomedical Science
Beats
Food & Drink,Health Lifestyle, Travel Arts & Entertainment, Parenting
Cannabis and infant and baby products.
Content
Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2 - Nature Communications
By Zhong-Liang Wang, Lily Wang, Shu-Yi Lin, Lu-Hai Wang, Hui-Chun Cheng| Nature Verified AbstractMost cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glycolytic metabolites for macromolecule synthesis needed for rapid proliferation.
CD24a knockout transforms the tumor microenvironment from cold to hot by promoting tumor-killing immune cell infiltration in a murine triple-negative breast cancer model
By Shih-Hsuan Chan, Lu-Hai Wang, Hsuan-Jung Tseng| bioRxiv@ AbstractBackground: CD24 plays a crucial role not only in promoting tumor progression and metastasis but also in modulating macrophage-mediated anti-tumor immunity. However, the impact of tumor CD24 on the immune landscape of the tumor microenvironment (TME) remains poorly explored. Here, we investigated the role of CD24a, murine CD24 gene, in the progression and immune dynamics of the tumor microenvironment (TME) in the 4T1 murine model of triple-negative breast cancer (TNBC).
Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2 - Nature Communications
By Zhong-Liang Wang, Lily Wang, Shu-Yi Lin, Lu-Hai Wang, Hui-Chun Cheng| Nature Verified AbstractMost cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glycolytic metabolites for macromolecule synthesis needed for rapid proliferation.
Company Info
Journal of Biomedical Science
Pittsburgh, Pennsylvania, United States
+1 412-268-2000