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Lucy Bird
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Senior Editor, Nature Reviews Immunology
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By Lucy Bird| Nature Verified Stem cell-like memory CD8+ T (TSCM) cells are crucial for long-lived immune memory. But it is not clear how best to induce this population with vaccines or immunotherapy. A study now shows that transient blockade of type I interferon receptor (IFNAR) during T cell priming enhances TSCM cell generation after viral infection and mRNA vaccination.
By Lucy Bird| Nature Verified Tumour-infiltrating lymphocytes (TILs) face a barrage of factors in the tumour microenviroment that affect their metabolism and impair their ability to eradicate tumour cells. Investigating the mechanisms behind this dysfunction, Ikeda et al. show that tumour cells transfer mitochondria containing mutated DNA to TILs, which reprogrammes their metabolism and compromises their functions.
By Lucy Bird| Nature Verified Stem cell-like memory CD8+ T (TSCM) cells are crucial for long-lived immune memory. But it is not clear how best to induce this population with vaccines or immunotherapy. A study now shows that transient blockade of type I interferon receptor (IFNAR) during T cell priming enhances TSCM cell generation after viral infection and mRNA vaccination.
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Nature Reviews Immunology
London, England, United Kingdom
+44 20 7833 4000