Michael Hallek - Profile and Journalist Details
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Verified
Editorial Board, Blood Cancer Journal
Cologne
Beats
Representation In Film , Mental Health, Anti Racism , Body Positivity, Parenthood, Feminism , Asian American Identity
foreign policy, art, music, hobbies, etc.
Content
Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody - Nature Medicine
By Maximilian Merz, David Fandrei, Eva Heger, Viola Schweinsberg, Uwe Platzbecker, Michael Hallek, Kristin Reiche, Florian Große, Nhu-Nguyen Pham| Nature Verified AbstractChimeric antigen receptor (CAR) T cells and bispecific T cell engagers have become integral components in the treatment of relapsed/refractory multiple myeloma. We report a 63-year-old male who received ciltacabtagene autoleucel CAR T cells and the GPRC5D × CD3 bispecific talquetamab for early relapse of his multiple myeloma. Nine months after CAR T therapy, he developed a symptomatic leukemic peripheral T cell lymphoma with cutaneous and intestinal involvement.
By Michael Hallek| Wiley Online Library Verified 1 Introduction and Disease Overview In the most recent update of the SEER database, the age-adjusted incidence of chronic lymphocytic leukemia (CLL) was 4.6 per 100 000 inhabitants per year [1], which makes CLL the most common type of leukemia. The median age at diagnosis is 70 years [1]. Less than 10% of patients with CLL are younger than 45 years. More male than female patients (1.9:1) are affected, and this gender effect seems to be stable across all ethnicities.
Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody - Nature Medicine
By Maximilian Merz, David Fandrei, Eva Heger, Viola Schweinsberg, Uwe Platzbecker, Michael Hallek, Kristin Reiche, Florian Große, Nhu-Nguyen Pham| Nature Verified AbstractChimeric antigen receptor (CAR) T cells and bispecific T cell engagers have become integral components in the treatment of relapsed/refractory multiple myeloma. We report a 63-year-old male who received ciltacabtagene autoleucel CAR T cells and the GPRC5D × CD3 bispecific talquetamab for early relapse of his multiple myeloma. Nine months after CAR T therapy, he developed a symptomatic leukemic peripheral T cell lymphoma with cutaneous and intestinal involvement.
Company Info
Blood Cancer Journal
Hoboken, New Jersey, United States
'+1 201-748-6000