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Anchor and Host, WNEW-FM - NEW 102.7 (New York, NY)
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Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development
By Eunah Chung, Fariba Nosrati, Mike Adam Verified, Andrew Potter| bioRxiv@ AbstractBackground: The thin descending limb of the loop of Henle is crucial for urine concentration, as it facilitates passive water reabsorption. Despite its importance, little is known about how this nephron segment forms during kidney development. Methods: We assembled a large single-cell RNA sequencing (scRNA-seq) dataset by integrating multiple datasets of non-mutant developing mouse kidneys to identify developing thin descending limb cells.
By Robyn Allen, Mike Adam Verified, Ashley W. Seifert, Emilio Oviedo Rivadeneira| bioRxiv@ AbstractCell proliferation is an elemental feature of epimorphic regeneration in vertebrate taxa. We previously reported that in contrast to fibrotic repair observed in laboratory mouse (Mus) strains, highly regenerative spiny mice (Acomys spp.) exhibit cell cycle progression and cell proliferation to faithfully replace missing tissue. However, little is known about proliferation dynamics, and specific cell types and states that may contribute to complex tissue regeneration in mammals.
Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development
By Eunah Chung, Fariba Nosrati, Mike Adam Verified, Andrew Potter| bioRxiv@ AbstractBackground: The thin descending limb of the loop of Henle is crucial for urine concentration, as it facilitates passive water reabsorption. Despite its importance, little is known about how this nephron segment forms during kidney development. Methods: We assembled a large single-cell RNA sequencing (scRNA-seq) dataset by integrating multiple datasets of non-mutant developing mouse kidneys to identify developing thin descending limb cells.
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WNEW-FM - NEW 102.7 (New York, NY)