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Nina Molina
Verified
New York
History and Heritage
Content
Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding
By Andreas Mueller, Nina Molina Verified, Seth A. Darst| bioRxiv@ AbstractBacterial σ factors bind RNA polymerase (E) to form holoenzyme (Eσ), conferring promoter specificity to E and playing a key role in transcription bubble formation. σN is unique among σ factors in its structure and functional mechanism, requiring activation by specialized AAA+ ATPases. EσN forms an inactive promoter complex where the N-terminal σN region I (σN-RI) threads through a small DNA bubble.
By Jane Black, Aleksandra Crapanzano Verified, Matthew Kronsberg Verified, Nina Molina Verified| The Wall Street Journal Verified Cooks fuel the holiday season with feverish bouts of baking and epic meals. Now is the time to honor their efforts and the care they bring to them with gifts distinguished by impressive hand-craftsmanship or the high quality of their raw materials. A sprinkle of the purest salt hand-harvested from the fjords of Iceland. A ceramic pot thrown with Colombian river clay. A baking mix dreamed up by an artisan chocolatier in Maine.
Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding
By Andreas Mueller, Nina Molina Verified, Seth A. Darst| bioRxiv@ AbstractBacterial σ factors bind RNA polymerase (E) to form holoenzyme (Eσ), conferring promoter specificity to E and playing a key role in transcription bubble formation. σN is unique among σ factors in its structure and functional mechanism, requiring activation by specialized AAA+ ATPases. EσN forms an inactive promoter complex where the N-terminal σN region I (σN-RI) threads through a small DNA bubble.
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