Sarah Crunkhorn - Profile and Journalist Details
Find journalists that align with your industry, location and vision. Unlock Sarah Crunkhorn's full journalist profile, including location, coverage topics, current employer, biography and preferences. Sign up today and start building journalist relationships that fuel your startup's growth.
Get connected with journalists today
Sarah Crunkhorn
Verified
Senior Editor, Nature Reviews Drug Discovery
Concord
Beats
world music, iran refugees, lgbt issues lgbt health,immigration middle east, health latino community
Wait. You can say no?
Content
By Sarah Crunkhorn Verified| Nature Verified IN BRIEF 06 May 2022 The mechanism by which the immunotherapeutic target LAG3 — an inhibitory receptor expressed on activated T cells — inhibits T cell function remains unknown. Using T cells isolated from mice, Guy et al. show that LAG3 can inhibit T cell function in the absence of its canonical ligand, MHC class II. Of note, existing LAG3 therapeutics target the LAG3–MHC class II interaction.
By Sarah Crunkhorn Verified| Nature Verified IN BRIEF 06 May 2022 Natural killer (NK) cell-based immunotherapy is an attractive anticancer strategy, but efficacy in clinical trials has been limited. Here, Pan et al. demonstrate that NK cells induce mitochondrial apoptosis of cancer cells, which is essential for NK cell-mediated killing. BH3 profiling — which measures mitochondrial sensitivity to BH3 peptides — showed that NK cells primed cancer cells for mitochondrial apoptosis.
By Sarah Crunkhorn Verified| Nature Verified IN BRIEF 06 May 2022 The mechanism by which the immunotherapeutic target LAG3 — an inhibitory receptor expressed on activated T cells — inhibits T cell function remains unknown. Using T cells isolated from mice, Guy et al. show that LAG3 can inhibit T cell function in the absence of its canonical ligand, MHC class II. Of note, existing LAG3 therapeutics target the LAG3–MHC class II interaction.
Company Info
Nature Reviews Drug Discovery
London, England, United Kingdom
+44 20 7833 4000