Sarah Hoelzl - Profile and Journalist Details
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Sarah Hoelzl
Verified
Founder and Host, The Purple Stars Podcast
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Content
By Tim Hasenbein, Sarah Hoelzl Verified, Stefan Engelhardt, Daniel Andergassen| bioRxiv@ AbstractA large proportion of disease variants is found in non-coding RNAs (ncRNAs), gene loci that have been identified as key regulatory elements. However, for most ncRNAs, their targets are unknown, hindering our ability to understand complex diseases. Here, we found that allele-specific ncRNAs were enriched nearby allelic protein-coding genes (pcGenes), suggesting that the allele-specific information could be used to predict cis-acting ncRNA-targets.
X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes - Nature Communications
By Tim Hasenbein, Sarah Hoelzl Verified, Zachary Smith, Chiara Gerhardinger, Oana Amarie, Lore Becker, Sabine M. Hölter, Birgit Rathkolb, Adrian Sanz-Moreno, Wolfgang Wurst, Valerie Gailus-Durner, Alexander Meissner, Stefan Engelhardt, John L. Rinn, Markus Kraiger| Nature Verified AbstractThe lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci providing the platform for the largest conserved chromatin structures. Here, we characterize the epigenetic profile of these loci, revealing them as the most female-specific accessible regions genome-wide.
By Tim Hasenbein, Sarah Hoelzl Verified, Stefan Engelhardt, Daniel Andergassen| bioRxiv@ AbstractA large proportion of disease variants is found in non-coding RNAs (ncRNAs), gene loci that have been identified as key regulatory elements. However, for most ncRNAs, their targets are unknown, hindering our ability to understand complex diseases. Here, we found that allele-specific ncRNAs were enriched nearby allelic protein-coding genes (pcGenes), suggesting that the allele-specific information could be used to predict cis-acting ncRNA-targets.
Company Info
The Purple Stars Podcast
United States, United States