Sebastian Köhler - Profile and Journalist Details
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Online Editor, Berliner Morgenpost
Baden-Württemberg
Beats
Conflict, Foreign policy, Royals , Defense, Europe, Foreign affairs, Diplomacy, United Kingdom, Terrorism, Politics , England, Migration , Military, Britain, General News, Veterans , Cyberwarfare, Human rights
I don't cover anything if it doesn't have to do with Fashion.
Content
Bcl-2 Oligomerizes Bax on the Mitochondrial Membrane Surface Preventing the Initial Stages of Apoptosis
By Sebastian Köhler, Sophie E Ayscough, Luke Ashley Clifton, Jörgen Ådén| bioRxiv@ AbstractThe Bcl-2 family of proteins control mitochondrial outer membrane (MOM) pore formation, crucial to cellular clearance via apoptosis. However, the molecular principles by which opposing family members inhibit, mediate or promote MOM perforation remain elusive. Here, we demonstrate that cell-protecting Bcl-2 directly sequesters cell-killing Bax into a protein-protein complex at the membrane interface preventing Bax forming apoptotic pores.
By Sebastian Köhler| MSN Deutschland Verified Microsoft tritt für den Schutz Ihrer Privatsphäre ein. Microsoft und unsere Drittanbieter verwenden Cookies, um Informationen wie eindeutige IDs zu speichern und darauf zuzugreifen, um unsere Dienste und Anzeigen bereitzustellen, zu pflegen und zu verbessern. Wenn Sie zustimmen, personalisieren MSN und Microsoft Bing die angezeigten Inhalte und Anzeigen.
Bcl-2 Oligomerizes Bax on the Mitochondrial Membrane Surface Preventing the Initial Stages of Apoptosis
By Sebastian Köhler, Sophie E Ayscough, Luke Ashley Clifton, Jörgen Ådén| bioRxiv@ AbstractThe Bcl-2 family of proteins control mitochondrial outer membrane (MOM) pore formation, crucial to cellular clearance via apoptosis. However, the molecular principles by which opposing family members inhibit, mediate or promote MOM perforation remain elusive. Here, we demonstrate that cell-protecting Bcl-2 directly sequesters cell-killing Bax into a protein-protein complex at the membrane interface preventing Bax forming apoptotic pores.
Company Info
Berliner Morgenpost