Steven Salzberg - Profile and Journalist Details
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Steven Salzberg
Verified
Professor and Contributor, Forbes
Maryl
Beats
lifestyle beautyFashion travel
Nothing really
Content
Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling
By Caleb Hallinan, Hyun Ji, Steven Salzberg, Jean Fan| bioRxiv@ AbstractThe accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to something other than the target gene, can distort a gene's true expression profile, making probe specificity essential for reliable transcriptomics.
OpenSpliceAI: An efficient, modular implementation of SpliceAI enabling easy retraining on non-human species
By Kuan-Hao Chao, Alan Mao, Anqi Liu, Steven Salzberg| bioRxiv@ AbstractThe SpliceAI deep learning system is currently one of the most accurate methods for identifying splicing signals directly from DNA sequences. However, its utility is limited by its reliance on older software frameworks and human-centric training data. Here we introduce OpenSpliceAI, a trainable, open-source version of SpliceAI implemented in PyTorch to address these challenges.
Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling
By Caleb Hallinan, Hyun Ji, Steven Salzberg, Jean Fan| bioRxiv@ AbstractThe accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to something other than the target gene, can distort a gene's true expression profile, making probe specificity essential for reliable transcriptomics.
Company Info
Forbes
Maryland, United States